Relative bioavailability of nicotine from a nasal spray in infectious rhinitis and after use of a topical decongestant
Identifieur interne : 000811 ( new/Analysis ); précédent : 000810; suivant : 000812Relative bioavailability of nicotine from a nasal spray in infectious rhinitis and after use of a topical decongestant
Auteurs : E. Lunell [Suède] ; L. Molander [Suède] ; M. Andersson [Suède]Source :
- European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1995-03-01.
English descriptors
- KwdEn :
- Teeft :
- Adverse events, Baseline nicotine concentration, Bioavailability, Bioequivalence, Bioequivalence ranges, Blood flow, Blood samples, Clin pharmacokinet, Cmax, Concurrent administration, Confidence intervals, Decongestant, Drug administration, First dose, Infectious rhinitis, Intranasal, Intranasal administration, Intranasal nicotine, Minor proportion, Minor reduction, Nasal, Nasal cavity, Nasal discharge, Nasal mucosa, Nasal mucosal blood flow, Nasal nicotine solution, Nasal obstruction, Nasal spray, Nasal vasoconstrictor decongestant, Nicotine, Nicotine absorption, Nicotine behaviour, Nicotine patch, Normal health, Peak concentration, Peak plasma concentration, Pharmacokinetic, Plasma curve, Present study, Rapid absorption, Rhinitis, Rhinitis rhinitis, Rhinitis xylometazoline, Smoking cessation, Smoking cessation products, Tmax, Topical decongestant, University hospital, Vasoconstrictor, Vasoconstrictor xylometazoline, Xylometazoline.
Abstract
Abstract: The relative bioavailability of nicotine from a nasal spray was assessed in 15 smokers suffering a common cold and rhinitis according to generally accepted criteria. The patients were given a single dose of 2 mg nicotine from the nasal spray with and without concurrent administration of a nasal vasoconstrictor decongestant, xylometazoline, in randomised order. Control session measurements were made in the disease-free state. Applying strict bioequivalence criteria, we found that common cold/rhinitis slightly reduced the bioavailability of nicotine, both in its rate and extent; the geometric mean of the ratio of Cmax, AUC and tmax were 0.81, 0.93 and 1.36, respectively. The nasal vasoconstrictor, xylometazoline, normalised the extent of the bioavailability of nicotine, but further prolonged the time for absorption to almost twice that measured in the disease-free state, increasing the tmax ratio to 1.72. The results suggest that a minor proportion of people stopping smoking with the help of a nicotine nasal spray may experience a minor reduction in the effect of the spray during common cold/rhinitis. However, the nicotine self-titration behaviour found with most smoking cessation products (except the nicotine patch) will automatically lead to an adjustment of the dosage to achieve the desired effect.
Url:
- https://api.istex.fr/ark:/67375/1BB-PJ4Q91WT-1/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087527
DOI: 10.1007/BF00202176
Affiliations:
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<term>xylometazoline</term>
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<term>Bioequivalence</term>
<term>Bioequivalence ranges</term>
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<term>Blood samples</term>
<term>Clin pharmacokinet</term>
<term>Cmax</term>
<term>Concurrent administration</term>
<term>Confidence intervals</term>
<term>Decongestant</term>
<term>Drug administration</term>
<term>First dose</term>
<term>Infectious rhinitis</term>
<term>Intranasal</term>
<term>Intranasal administration</term>
<term>Intranasal nicotine</term>
<term>Minor proportion</term>
<term>Minor reduction</term>
<term>Nasal</term>
<term>Nasal cavity</term>
<term>Nasal discharge</term>
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<term>Nasal mucosal blood flow</term>
<term>Nasal nicotine solution</term>
<term>Nasal obstruction</term>
<term>Nasal spray</term>
<term>Nasal vasoconstrictor decongestant</term>
<term>Nicotine</term>
<term>Nicotine absorption</term>
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<term>Nicotine patch</term>
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<term>Peak concentration</term>
<term>Peak plasma concentration</term>
<term>Pharmacokinetic</term>
<term>Plasma curve</term>
<term>Present study</term>
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<term>Rhinitis rhinitis</term>
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<term>Tmax</term>
<term>Topical decongestant</term>
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<front><div type="abstract" xml:lang="en">Abstract: The relative bioavailability of nicotine from a nasal spray was assessed in 15 smokers suffering a common cold and rhinitis according to generally accepted criteria. The patients were given a single dose of 2 mg nicotine from the nasal spray with and without concurrent administration of a nasal vasoconstrictor decongestant, xylometazoline, in randomised order. Control session measurements were made in the disease-free state. Applying strict bioequivalence criteria, we found that common cold/rhinitis slightly reduced the bioavailability of nicotine, both in its rate and extent; the geometric mean of the ratio of Cmax, AUC and tmax were 0.81, 0.93 and 1.36, respectively. The nasal vasoconstrictor, xylometazoline, normalised the extent of the bioavailability of nicotine, but further prolonged the time for absorption to almost twice that measured in the disease-free state, increasing the tmax ratio to 1.72. The results suggest that a minor proportion of people stopping smoking with the help of a nicotine nasal spray may experience a minor reduction in the effect of the spray during common cold/rhinitis. However, the nicotine self-titration behaviour found with most smoking cessation products (except the nicotine patch) will automatically lead to an adjustment of the dosage to achieve the desired effect.</div>
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